Starting in Dynamics SL 2018 CU1, Transport Data Encryption (TDE) is supported.
To enable TDE in your Dynamics SL database(s), edit the below script by adding a strong password and entering the appropriate SL database name. Then, run it in SQL Management Studio. No additional configuration is needed.
USE master;
GO
CREATE MASTER KEY ENCRYPTION BY PASSWORD = '<UseStrongPasswordHere>';
go
CREATE CERTIFICATE MyServerCert WITH SUBJECT = 'My DEK Certificate';
go
USE <Dynamics SL Database name>;
GO
CREATE DATABASE ENCRYPTION KEY
WITH ALGORITHM = AES_128
ENCRYPTION BY SERVER CERTIFICATE MyServerCert;
GO
ALTER DATABASE <Dynamics SL Database name>
SET ENCRYPTION ON;
GO